C. Uetrecht

Variant-specific nucleocapsid mutations shape host innate immune trajectories during SARS- CoV-2 infection

It is found that the mutations induce distinct transcriptional and translational alterations: rN-Alpha drives a stealth-like infection characterized by sustained translation efficiency and specific evasion of the 2’-5’-oligoadenylate synthetase (OAS) innate immune sensor, whereas rN-Delta and rN-BA trigger a highly ele...