C. T. Nguyen

A p53R273H-selective bispecific T cell engager: Computational design and functional validation

TP53 mutations occur in over 50% of human cancers and generate shared neoantigens, including p53R273H, which represents a compelling target for precision immunotherapy. However, HLA allele-specific presentation and the risk of off-target toxicity remain major challenges. Here, we developed a group of bispecific T cell...