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Author

C. Swanton

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Review Open access Aug 2026

Integrated MB-PhD training is a long-term investment in the clinician-scientist workforce

Background: Clinician-scientists translate clinical observation into discovery, trials, and policy, yet this workforce is shrinking across health systems worldwide. Integrated MB-PhD training, pausing medical training to complete a PhD before clinical exposure or specialisation, is one route into this career. We aimed...

D. Jafree, M. Sun, G. Stewart et al. · 0 citations
Review Aug 2026

Charting intratumor heterogeneity from bench to bedside

The current understanding of heterogeneity and evolution is synthesized and it is discussed how these insights can inform the development of evolution-aware diagnostic and therapeutic strategies.

J. Wan, N. Mcgranahan, C. Swanton · 0 citations
Open access Sep 2026

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

Extrachromosomal DNA (ecDNA) is a major driver of cancer pathogenesis, however, its spatial organization in the nucleus is not currently understood. Here we show that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing. Single-molecule multi-omic...

Yan-Bo Wang, Xiao-Wei Yan, Natasha E. Weiser et al. · 0 citations

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