Author

C. Swale

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Open access Oct 2026

Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans

Regeneration requires injured tissues to selectively reactivate certain developmental programs while triggering regeneration-specific mechanisms and responding to the immediate consequences of tissue damage. How chromatin states are reorganized during this transition, and whether the underlying sequence of regulatory e...

Maëlle Louvier, Gillian Forbes, Mahmood Mohammed-Ali et al. · bioRxiv · 0 citations

Open access Oct 2026

Pentachloropseudilin disrupts multiple steps of the Toxoplasma gondii lytic cycle, consistent with predicted multi-myosin engagement

Multiple points of PCIP-induced failure are revealed throughout the T. gondii lytic cycle and associate distinct phenotypes with MyoA, MyoF- and MyoJ-dependent functions, establishing PCIP as a chemical probe for dissecting apicomplexan myosin-dependent processes and support multi-myosin interference as a promising ant...

Romane Agresti, Faraj Gtat, Guillaume Drumont et al. · bioRxiv · 0 citations

Open access Aug 2026

Divergent SAGA complexes shape the Toxoplasma transcriptome for lytic cycle progression and host interaction

Histone acetylation governs Toxoplasma gondii gene expression, developmental plasticity and virulence, yet the organization and deployment of its acetyltransferase machinery remain poorly understood. Here, we show that T. gondii rewired this process using a plant-like system built around the acetyltransferase TgGCN5b,...

D. Cannella, Belén Pachano, Martina Shahinas et al. · Nature Communications · 0 citations