Open access
Jul 2026
Robust Myocardial Regeneration After Selective Cardiomyocyte Loss Is Driven by Cardiac Stem Cell Activation Through the miR-221–p57 Axis
Mechanistically, it is shown that miR-221-dependent repression of p57 governs the transition from quiescence--to activation—to differentiation—to quiescence of the CSCs, defining a reversible regulatory program which, under the proper conditions, endows the adult myocardium with robust CM regenerative competence.
E. Cianflone, F. Marino, Mariangela Scalise et al.
· bioRxiv · 0 citations