Author

C. Siniscalchi

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Review Open access Aug 2026

From frailty-driven to frailty-informed care in the age of wearable AI

As populations age, frailty is increasingly monitored through wearable technologies capable of continuously capturing behavioral and physiological change. While these systems enable earlier detection of vulnerability, they also risk transforming probabilistic signals into rigid clinical thresholds. We propose a frailty...

E. Bignami, Mattia Madeo, C. Siniscalchi et al. · Communications Medicine · 0 citations

Review Open access Sep 2026

Personalized anticoagulant therapy in venous thromboembolism: current role of direct oral anticoagulants, unmet clinical needs, and future perspectives on Factor XI inhibition

Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, remains a major cause of morbidity and mortality worldwide. The introduction of direct oral anticoagulants (DOACs) has transformed the management of VTE by providing effective and convenient alternatives to vitamin K antagonists. Ho...

C. Siniscalchi, A. Perrella, U. Trama et al. · Frontiers in Pharmacology · 0 citations

Review Open access Sep 2026

Lipid Metabolism, Statins and Bleeding Risk During Anticoagulant Therapy: Emerging Pharmacological Insights.

Lipid metabolism, coagulation, inflammation, and vascular integrity are closely interconnected biological systems. Although statins are primarily prescribed to reduce low-density lipoprotein cholesterol (LDL-C) and prevent atherosclerotic cardiovascular disease, increasing evidence indicates that these agents exert mul...

C. Siniscalchi, M. Basaglia, A. Perrella et al. · Pharmazie · 0 citations