Author

C. Sanchez-Santos

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Review Open access Sep 2026

Innovative therapies under clinical development for ALS treatment. Part 2: biologics and natural products.

This review provides a structured overview of biologics and natural products in the ALS clinical pipeline, with particular emphasis on candidates that entered, advanced through, or completed clinical evaluation between 2022 and the end of 2025.

C. Huang, C. Sanchez-Santos, L. Martínez-González et al. · Expert Opinion on Investigat... · 0 citations

Open access Jul 2026

Selective Brain-Penetrant TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy

It is found that these inhibitors reduce TDP-43 phosphorylation levels in neuroblastoma cells and FTD patient-derived models, and restores cognitive deficits, conferred neuroprotection in the frontal cortex, and reduced microglial activation in an FTD-TDP mouse model, supporting its therapeutic potential.

Cecilia Sanchez-Santos, Alberto Jiménez-Amor, Loreto Martínez-González et al. · Journal of Medicinal Chemist... · 0 citations