p63 and p73 drive cutaneous squamous cell carcinoma through convergent transcriptional control of EGFR signaling.
Aberrant transcriptional regulation is central to squamous cell carcinoma (SCC), but how related lineage transcription factors coordinate oncogenic programs is poorly understood. We show that TP73, together with TP63, is upregulated in skin SCC and is required for tumorigenesis. Using chromatin profiling, transcriptomi...