Gliomas and particularly glioblastomas, represent the most aggressive and treatment-resistant brain tumours. Current standard treatments, including surgical resection, radiotherapy and chemotherapy, offer only limited long-term survival benefits. The highly immunosuppressive tumour microenvironment that characterizes g...
Georgios Kallivokas, Vasileia-Rafaella Karmaniola, Panagiotis G. Vrettos et al.· Biochimica et biophysica act...· 0 citations
Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase SUV4–20H2 (KMT5C) are critical regulators of chromatin integ...
A. Giannopoulou, Elisavet Kosma, Dimitrios S. Kanakoglou et al.· Neurotherapeutics· 0 citations
Structural and functional aspects of PRC2 are described, with emphasis on the potential of this epigenetic context-dependent regulator to integrate developmental, environmental and aging-related signals, to shape the transcriptional landscape of aging brain.
Maria A Katsianou, E. Vetsika, Mariam Markouli et al.· Biomolecules· 1 citation
Findings indicate that impaired epigenetic maintenance, especially in repetitive genome regions, plays a key role in biological aging of neurons and glial cells and the potential of targeting LINE-1 methylation to restore methylation homeostasis, epigenetic stability and delay brain aging.
Alkinoos A. Armoundas, C. Piperi· Mechanisms of Ageing and Dev...· 0 citations
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