Author

C. Paweletz

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Sep 2026

Spatially confined IL-12 programs CAR-NK through mTORC1 to coordinate antitumor immune networks.

Solid tumors evade immunotherapy because of immunosuppressive microenvironments that limit immune cell persistence and function. Although interleukin-12 (IL-12) potently activates antitumor immunity, its clinical use has been constrained by systemic toxicity. Here we engineered a CAR natural killer (NK) cell platform t...

Mubin Tarannum, K. Dinh, Mila Stanojevic et al. · Cancer Discovery · 0 citations

Open access Sep 2026

Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection

Findings define mechanisms by which tumors restrict targetable truncal truncal neoantigen display and suggest immunopeptidome shift strategies to circumvent immune escape.

Koji Haratani, Bruce R. Reinhold, J. Duke-Cohan et al. · Immunity · 1 citation

Aug 2026

Therapeutic targeting of RAS-mediated resistance in oncogene-driven lung cancer.

RAS alterations mediate resistance to targeted agents in approximately 10% of oncogene-driven lung cancer, and Rational combinations with novel RAS inhibitors are effective in preclinical models, providing the basis for their clinical investigation and extending the paradigm of precision oncology.

F. Facchinetti, L. Friboulet, L. Liao et al. · Annals of Oncology · 0 citations