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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

C. O. Akintayo

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Review Open access Jul 2026

Engineering CAR-T cells for solid tumors: Overcoming the microenvironment through integrated design and clinical translation

This review synthesizes the mechanistic insights, engineering strategies, clinical evidence, and emerging platforms, including in vivo lentiviral CAR-T generation, that define the current landscape, and proposes a tiered framework for next-generation solid tumor CAR-T development, while explicitly acknowledging the limitations and unknowns that persist.

Samuel Obiosa Onyekweli, Gloria Osayamen Omoruyi, C. O. Akintayo et al. · 0 citations

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