Multiregion profiling of genomic and transcriptional heterogeneity in head and neck squamous-cell carcinoma
Background Intratumoral heterogeneity (ITH) is thought to contribute to tumour evolution and treatment resistance but its biological and clinical significance in localised head and neck squamous-cell carcinoma (HNSCC) remains incompletely understood. Patients and methods In the prospective SCANDARE study, we analysed 8...