C. Ndumele

The therapeutic approach to cardiovascular-kidney-metabolic syndrome.

Predictive Utility of Coronary Artery Calcium Score Added to the PREVENT Atherosclerotic Cardiovascular Disease Equations.

Reclassification results support selective use of CAC in those with borderline to intermediate risk estimated by the PREVENT-ASCVD equations, and in some groups, did not change model discrimination and reclassification.

Prediabetes, Malignant Left Ventricular Hypertrophy, and Risk of Incident Heart Failure Among Hypertensive Adults

Among hypertensive adults, the coexistence of prediabetes and malignant LVH identifies a subgroup at substantially elevated HF risk, and integrating glycemic status, ECG findings, and cardiac biomarkers may enhance HF risk stratification and inform preventive strategies.

Large-scale proteomics to identify novel biomarkers linking social determinants of health to heart failure risk

Protein biomarkers associated with SDOH burden and HF risk are demonstrated and potentially causal effect of C1q tumor necrosis factor–related protein 1 (C1QTNF1), an adiponectin paralog, on HF is suggested.

External Validation of the PREVENT Equations in a National Sample of US Adults.

The PREVENT equations accurately and precisely estimate the 10-year risk of CVD, ASCVD, and HF in a large sample of US adults and support the generalizability of the PREVENT equations to inform guideline-recommended risk assessment and preventive efforts.