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Case report Open access Aug 2026

Single-session combined mitral transcatheter edge-to-edge repair and left atrial appendage occlusion using a steerable introducer after a mitral repair-oriented transseptal puncture: a case report

Abstract Background Combined mitral transcatheter edge-to-edge repair (M-TEER) and left atrial appendage occlusion (LAAO) may be considered in selected high-risk patients with severe mitral regurgitation (MR) and atrial fibrillation (AF). However, the optimal transseptal puncture site differs between procedures, potent...

M. Bonanni, Matteo Pelliccia, G. D. De Sanctis et al. · 0 citations
Open access Aug 2026

Left atrial appendage closure versus medical therapy in atrial fibrillation: An updated meta-analysis of randomized trials on the trade-off between stroke prevention and bleeding.

BACKGROUND Long-term oral anticoagulation remains the standard of care for patients with atrial fibrillation, despite the non-negligible risk of bleeding. Percutaneous left atrial appendage closure (LAAC) has emerged as an alternative strategy for preventing stroke with inconclusive modern data. AIMS Our aim was to e...

G. Di Pietro, Riccardo Improta, E. Bruno et al. · 0 citations

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