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This work uncovered Uhrf1‐dependent PKM2 ubiquitination/degradation as a previously unrecognized therapeutic axis for IBD, while positioning EPT as a molecular glue capable of targeting the Uhrf1–PKM2 complex.
This study investigated the protective mechanisms of Chinese yam polysaccharide (CYP) against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice, focusing on intestinal barrier repair, gut microbiota-mediated effects, and host lipid metabolic regulation. CYP treatment alleviated disease severity and r...
Surprisingly, substitution of the trifluoromethyl group of TPPU with a pentafluorosulfanyl substituent restored potency against human sEH, leading to the identification of a promising hit compound and the utility of the underexplored pentafluorosulfanyl group and the TBS strategy for optimizing amide‐based sEH inhibito...
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