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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

C. Miele

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Open access Oct 2026

Methylglyoxal hampers the angiogenic capacity of human retinal endothelial cells modifying cell transcriptome with the contribution of NRSF/REST

The functional impairment of retinal microvascular cells is an early and central event in diabetic retinopathy (DR). Methylglyoxal (MGO), the most reactive precursor of advanced glycation end products (AGEs), has been implicated in vascular injury and neuro-retinal dysfunction. Its direct effects on retinal endothe...

M. Aprile, C. Nigro, Caterina Perfetto et al. · 0 citations
Open access Sep 2026

181. Integrating clinical profiles and microRNAs to uncover molecular mechanisms in treatment-resistant schizophrenia

Findings suggest that increased expression of these miRNAs may enhance gene silencing across synaptic and intracellular signaling cascades, potentially contributing to impaired neuroplasticity and treatment resistance through downregulation of critical neurotransmission-related targets.

L. Vellucci, P. Mirra, A. Nasti et al. · 0 citations
Open access Jul 2026

Blood-Based DNA Methylation Models Improve Short-term Cardiovascular Risk Stratification in Individuals With Type 2 Diabetes

The DNAm-based models generated may improve risk stratification for short-term cardiovascular events in individuals with T2DM, providing a promising approach to refine identification of those at increased risk of MACE.

M. Longo, Antonella Desiderio, M. Masulli et al. · 0 citations

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