C. Mamie

T-Cell Specific Deletion of PTPN23 Alters T-Cell Development and TCRαβ/γδ Composition

Highlights What are the main findings? T-cell–specific deletion of PTPN23 causes a marked reduction in T-cells, accompanied by preferential accumulation of TCRγδ T-cells and enrichment of differentiated effector/memory T-cell subsets. Multi-omics and single-cell RNA sequencing reveal alterations in T-cell developmental...