C. Liguori

Diagnosing Lennox-Gastaut syndrome in adulthood: A scoping review of diagnostic challenges and age-related electroclinical evolution.

OBJECTIVE Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood is challenged by disease evolution, treatm...

The orexinergic system in Alzheimer's disease: from sleep disruption to accelerated neurodegeneration.

Sleep disorders in adults with Cri du Chat syndrome: A questionnaire-based study.

The prevalence, characteristics, and potential determinants of sleep disturbances in adults with CdC syndrome using standardized and validated scales and questionnaires are investigated, emphasizing the need for systematic sleep screening and multidisciplinary management in this population.

Sleep–neuroinflammation interactions in Alzheimer’s disease: a systematic review of biomarker pathways

The available evidence supports a biologically plausible, potentially bidirectional relationship between sleep disruption and AD pathology, while highlighting important gaps in translation.

Instrumental, Neurophysiological, cognitive and Sleep InvestiGations into the High risk of neurodegeneraTion in Late Onset Epilepsy of Unknown aetiology: the INSIGHT-LOEU study.

This strategy could improve the early detection of cognitive decline, guide personalised management, and ultimately enhance quality of life, while contributing to the long-term sustainability of healthcare systems in an ageing population, focusing on LOEU as a model for dementia prevention.