Author

C. L. Le Maitre

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Open access Sep 2026

Translating in silico micro-computed tomography bone scans into a 3D printable bone model

Personalised medicine is an expanding area of medical research, in which patient-specific physiology informs clinical interventions. The personalisation of skeletal-based medical implants through 3D imaging and additive manufacturing (AM) has the potential to improve patient outcomes and reduce the likelihood of implan...

L. Dascombe, David A. Chorlton, T. Nichol et al. · Frontiers in Bioengineering... · 0 citations

Open access Sep 2026

Extracellular Vesicles Drive Invasive Characteristics and Matrix Remodelling in Organotypic Models of Colorectal Cancer Progression

It is demonstrated that metastatic CRC‐derived EVs enhance invasive behaviour and remodel the ECM, creating a permissive microenvironment for metastasis.

Sonia Guarnerio, L. Cole, Rawan Maani et al. · Journal of Extracellular Bio... · 0 citations

Open access Sep 2026

Single-cell multi-omics defines H3K27me3 remodelling in intervertebral disc degeneration with implications for regenerative intervention

This study demonstrates that eliminating repressive histone marks, together with CRISPR-mediated gene transactivation, enhances TBXT gene expression in human NPCs derived from degenerated aged discs.

Deepani W. Poramba-Liyanage, Xiao-Le Tong, F. Riemers et al. · Bone Research · 0 citations