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Author

C. Jobichen

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2 papers indexed here

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Open access Oct 2026

Structural basis of coiled-coil domain-mediated inhibition of A. baumannii AbTir NAD+ nucleosidase activity

TIR (Toll/interleukin-1 receptor) domains are central components of innate immunity and cell-death pathways across diverse forms of life. In bacteria, TIR domain-containing proteins participate in diverse antiphage defence systems, several of which rely on NADase activity carried out by TIR domains. This nucleosidase a...

W. Gu, M. K. Manik, C. Jobichen et al. · 0 citations
Open access Sep 2026

A murine MHC-Ib molecule, H2-Q9, drives peptide-centric T cell receptor recognition of a viral antigen.

Highly polymorphic classical major histocompatibility complex class I (MHC-Ia) molecules present peptides to T cell receptors (TCRs) expressed on CD8+ T cells. In contrast, non-classical MHC-Ib molecules are less polymorphic, and the structural principles governing their recognition by TCRs remains poorly understood. H...

Luke Tennant, C. Jobichen, Mai T. Tran et al. · 0 citations

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