231. Multi-omic longitudinal profiling reveals functional and metabolic gut microbiota signatures predictive of antidepressant response in first episode, drug-naïve depression
Abstract Background Antidepressant treatment response is highly heterogeneous, and the biological mechanisms underlying this variability remain insufficiently understood. Emerging evidence suggests that gut microbiota and microbially derived metabolites influence neurobiological pathways relevant to antidepressant effi...