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Author

C. Gordon

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Open access Sep 2026

661. Vagus nerve stimulation reduces suicidal ideation in markedly treatment-resistant depression: RECOVER findings

Abstract Background Individuals with markedly treatment-resistant depression (mTRD) have substantial risk for suicide attempt and completion. Few antidepressant treatments offer benefit for suicide, and it is critical that novel treatments not increase/worsen suicidal ideation (SI) or behavior. Aims & Objectives Assess...

A. Rush, V. Hristidis, V. D. de Leon et al. · 0 citations
Review Aug 2026

The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions.

Over 80% of participants who achieved meaningful benefit in symptom, function, or QoL measures after 12 months of active VNS retained these benefits at the 18- and 24-month assessments, demonstrating remarkable durability in participants expected to relapse at high rates.

C. Conway, H. Sackeim, A. Rush et al. · 2 citations

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