Author

C. Evans-Molina

2 papers indexed here

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Sep 2026

β-Cell Dysfunction Identifies Individuals With Single Autoantibody Positivity at Increased Risk of Type 1 Diabetes Progression.

OBJECTIVE Individuals with single islet autoantibody positivity exhibit a highly variable risk for type 1 diabetes progression. We evaluated whether metabolic measures identify those at higher progression risk. RESEARCH DESIGN AND METHODS Among first- and second-degree relatives of persons with type 1 diabetes who sc...

E. K. Sims, Lu You, H. Ismail et al. · Diabetes Care · 0 citations

Open access Sep 2026

A Novel PD-L1 Splice Isoform Modulates β Cell Communication in Response to Interferon Signaling

β cell expression of the immune checkpoint ligand PD-L1 (encoded by CD274) limits autoimmune β cell destruction in type 1 diabetes (T1D). β cell display PD-L1 not only at the cell surface but also secreted on extracellular vesicles (EVs), which bind PD-1 and restrain CD8+ T cell activation. β cell IFN signaling is an e...

Chaitra Rao, Fei Huang, Saptarshi Roy et al. · bioRxiv · 0 citations