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Author

C. Dahia

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2 papers indexed here

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Open access Aug 2026

Mechanical Suppression of Sonic Hedgehog Signaling by Nucleus Pulposus Cells Underlies Early Disc Degeneration in Mouse

Sonic hedgehog (SHH) expression by nucleus pulposus (NP) cells is important for intervertebral disc development and maintenance. The lumbosacral disc, the most immobile region of the spine, lies adjacent to the sacrum and is most vulnerable to degeneration. We hypothesized that a lack of mobility represses SHH expressi...

S. Virk, Veeraj Shah, Vikrant Piprode et al. · 0 citations
Open access Sep 2026

Sonic Hedgehog Is An Important Regulator Of Intervertebral Disc Homeostasis And Rejuvenation

Intervertebral disc degeneration and associated neurological symptoms constitute a global health burden, yet no cure is currently available 1,2. Each disc consists of a central nucleus pulposus, surrounded by annulus fibrosus, and end plates connecting it to the growth plates of adjacent vertebral bodies. The notochord...

S. Mohanty, R. Anbazhagan, Paul E. Pricop et al. · 0 citations

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