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Author

C. Cuevas-Velazquez

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Open access Sep 2026

Intrinsically disordered regions in the NLRP family of receptors act as regulatory hubs for inflammasome condensation and activation

A critical role is uncovered for intrinsically disordered regions (IDRs) in activating NLRP1, NLRP3, and NLRP14 inflammasomes, suggesting that targeting the dynamics of phase transitions could open novel therapeutic avenues for treating inflammatory and autoimmune diseases.

Teresa Nava-Ramírez, C. Cuevas-Velazquez, Alejandra A. Covarrubias et al. · 0 citations

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