Author

C. Clish

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Open access Aug 2026

Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank

Age is a major risk factor for many diseases, but the biological processes driving aging are heterogeneous across individuals. Efforts to untangle differences between chronological and biological age have focused on identifying age-associated markers, such as ’omics clocks. Many ’omics features, including proteins, are...

M. Gillman, H. Chen, A. Howard et al. · bioRxiv · 0 citations

Open access May 2024

Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic target in Parkinson’s disease

Neuronal α-synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), lack disease-modifying therapies. We developed a Drosophila model for identifying novel glial-based therapeutic targets for α-synucleinopathies. In this model, human α-synuclein is expressed in neurons and individual g...

MJ Sodders, J. Ávila-Pacheco, EC Okorie et al. · bioRxiv · 1 citation