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Review Oct 2026

Noncoding RNAs in Cancer: Functions, Mechanisms, and Targeting Approaches.

Ninety-eight percent of the human transcriptome lacks protein-coding potential. A small fraction of this landscape comprises housekeeping noncoding RNAs (ncRNAs) with well-defined functions, whereas the heterogeneous group of regulatory ncRNAs, generated from ∼100,000 loci, acts through diverse mechanisms to control ge...

Juan J. Montero, C. Braun, Michael Sattler et al. · 0 citations
Open access Aug 2026

Targeting PRMT5 Inhibitor–Induced Adaptation in Pancreatic Cancer with the RBM39 Degrader Indisulam

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge. Next-generation protein arginine methyltransferase 5 (PRMT5) inhibitors show promising clinical results in a subset of PDACs with codeletion of the tumor-suppressor CDKN2A and the methylthioadenosine phosphorylase (MTAP) gene, but...

Valentina Spielmann, Jonas Buchloh, Selen Selcen et al. · 0 citations

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