An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer.
X-SPATIO is a spatially compatible computational pipeline designed to directly link hematoxylin and eosin morphology with region-matched mRNA and protein expression, enabling cost-effective inference of spatial biomarker expression and establishing a foundation for biologically grounded discovery and precision oncology in TNBC.