Author

C. Bertollini

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Open access Sep 2026

3D Imaging Without Light-Sheet: An Accessible Tissue-Clearing and Confocal Workflow for Human Cortical and Retinal Organoids

Human induced pluripotent stem cell (iPSC)-derived neural organoids have emerged as valuable models for investigating human neurodevelopment and neurological disorders. However, their complex three-dimensional architecture poses significant challenges for conventional histological approaches, which rely on physical sec...

Erica Debbi, L. Mautone, Chiara D'Antoni et al. · Organoids · 0 citations

Open access Jul 2026

Mutant Huntingtin disrupts neurogenic and astroglial programs via the EZH2-Let-7g-LIN28 axis with rescue by epigenetic modulators.

It is shown that neurogenesis is disrupted at multiple stages of lineage progression in both rodent and human neural stem cell models of Huntington's disease, and a panel of clinically relevant epigenetic compounds hold promise for stage-spanning therapeutic strategies capable of modifying disease trajectory.

Jessica Rosati, A. Casamassa, G. Ruotolo et al. · Cell Death and Differentiati... · 0 citations