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Author

C. An

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Sep 2026

A Progression-Associated Tumor-Reactive T-Cell Signature Predicts Immunotherapy Response and Reveals ICOS-High CD8 T-Cell Functional States in Head and Neck Squamous Cell Carcinoma.

A progression-associated T-cell signature, HNSC-TstcSig, is developed that predicts immunotherapy response and reflects immune-active tumor states in HNSCC and suggests that ICOS is associated with a tumor-reactive CD8 T-cell state characterized by cytotoxic activity and immune checkpoint-related features.

Shao-Qian Zhang, Xiao-Tong Yan, Xi-Chen Dong et al. · 0 citations
Review Open access Jul 2026

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

This review comprehensively examines the current evidence for diverse biomarkers predictive of HNSCC response to anti‐PD‐1/PD‐L1 therapy, including but not limited to PD‐L1 expression, tumor mutational burden, features of the tumor microenvironment (TME), and circulating biomarkers.

Xiao‐Tong Yan, Zhaohong An, C. An · 1 citation

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