Oct 2026
The NFIL3-MYC signaling axis: a novel therapeutic target and prognostic marker in high-risk multiple myeloma
D. Maichl, Wen-Hui Cheng, Poonam Kumari et al.
· Biomarker Research · 0 citations
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Open access
Sep 2026
Replication-coupled chromatin assembly cooperates with ATR/CHK1 signaling to suppress DNA damage and premature MMB-dependent mitotic transcription
Faithful genome duplication requires coordination of DNA replication, chromatin assembly, and checkpoint signaling to prevent inappropriate mitotic progression. Using a targeted siRNA screen for factors modulating CHK1 inhibitor-induced DNA damage and premature mitotic entry, we identified replication-coupled chromatin...
Devi Bala Murugan, D. Gertzmann, Merima Ramic et al.
· bioRxiv · 0 citations
Open access
Sep 2026
TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition.
Precise temporal activation of mitotic genes is essential for proper cell-cycle progression, yet the chromatin-based mechanisms coordinating this process remain incompletely understood. The B-MYB-MuvB (MMB) complex is a key regulator of mitotic gene expression and becomes hyperactivated following inhibition of the ATR-...
Franziska Liss, D. Gertzmann, Devi Bala Murugan et al.
· Cell Reports · 1 citation