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C. Acevedo‐Rocha

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Open access Sep 2026

Biocatalytic Production of Galantamine in Yeast through Cytochrome P450 Optimization

Galantamine is a pharmaceutically relevant Amaryllidaceae alkaloid used for the treatment of Alzheimer’s disease. Its structural complexity and low abundance in plants motivate the development of alternative manufacturing routes. Here, we established the first engineered yeast platform for the biocatalytic production o...

Maxence Holtz, Samantha de Haan, Cecília Castellví Domingo et al. · 0 citations
Open access Jul 2026

Hybrid quantum-classical de novo design of MHC-binding peptides

Deep generative models have become a leading approach for designing therapeutic molecules, yet efficiently exploring vast biomolecular sequence spaces remains difficult, particularly for targets with limited training data. The prior distribution that seeds a generative model shapes which regions of sequence space it ex...

E. S. Engdal, Jonathan Funk, O. Bacarreza et al. · 0 citations

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