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Open access Sep 2026

41 Clinical Utility of Ultrasensitive ctDNA Detection Across the Renal Cell Carcinoma Disease Spectrum: A Multi-Cohort Retrospective Study

Abstract Background Circulating tumor DNA (ctDNA) is an emerging tool for non-invasive disease monitoring in solid tumor oncology, yet its clinical utility in renal cell carcinoma (RCC) remains poorly defined. RCC exhibits variable ctDNA shedding rates, which may limit assay sensitivity particularly in low-burden disea...

Ezra Blumenthal, Paulo Siqueira Do Amaral, Yi Chen et al. · 0 citations
Open access Aug 2026

Circulating tumor DNA dynamics in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative early breast cancer assessed using an ultrasensitive tumor-informed assay

Background Circulating tumor DNA (ctDNA) in early breast cancer (EBC) is prognostic for distant relapses. The ctDNA dynamics in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative EBC, which is considered low-shedding, are challenging to track. We used an ultrasensitive assay to dete...

C. Barcenas, A. Contreras, A. Alexander et al. · 0 citations

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