Sauchinone-loaded chitosan nanoparticles simultaneously suppress NF-κB-driven inflammation, activate the Nrf2/HO-1 axis, and restore sarcolemmal utrophin in a murine model of Duchenne muscular dystrophy.
Duchenne muscular dystrophy (DMD) is driven by dystrophin loss, chronic NF-κB-dependent inflammation, impaired Nrf2 antioxidant signaling, and dystrophin-associated protein complex (DAPC) instability. Sauchinone has dual NF-κB-inhibitory and Nrf2-activating activity but poor oral bioavailability (<8%). We prepared sauc...