Author

Buthina A. Al-Oudat

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#protein folding Sep 2026

Optimization of a bis-imine scaffold as a glyoxalase I inhibitor: synthesis, SAR, and docking studies.

Overall, this study provides a clear innovative-driven SAR model for bis-imine-based Glo-I inhibitors and identified compound 8a as an optimized lead for the future design of anticancer candidates targeting Glo-I enzyme.

Buthina A. Al-Oudat, Farah B. Al-Omari, S. A. Audat et al. · Medicinal Chemistry Research · 0 citations