Phytochemical Characterization and Antipyretic and Antinociceptive Activities of Echinops orientalis Trautv. Methanolic Flower Extract: Evidence from In vivo Studies, Network Pharmacology and Molecular Docking.
Echinops orientalis MFE shows antipyretic and antinociceptive potential, supporting its traditional use and computational predictions suggest modulation of cyclooxygenase (COX-2), prostaglandin E2 receptor (EP2), thromboxane synthase (TBXAS1) and interconnected inflammatory pathways.