Tracing Hydrazine in Pharmaceuticals: Toxicological Concerns, Extraction Approaches, and Analytical Method Development
Hydrazine (N2H4) is a synthetic reagent that is used in the manufacturing of various active pharmaceutical ingredients (APIs) such as isoniazid, hydralazine, and carbidopa. The major concerns associated with its presence in medications as a residual reagent or degradation product arise because of its ability to damage...