Open access
Jul 2026
Hierarchical Contrastive Learning for Protein–Protein Interaction Prediction Across Organisms
HIPPO (HIerarchical Protein–Protein interaction prediction across Organisms), a hierarchical contrastive learning framework for PPI prediction, is introduced and it is suggested that structured biological knowledge can improve representation learning for PPI prediction across diverse and imbalanced datasets.
Shiyi Liu, Buwen Liang, Yuetong Fang et al.
· International Journal of Mol... · 0 citations