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Author

Bryan D. Bryson

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Open access Aug 2026

Identification of a spatially organized TREM2-associated permissive macrophage niche in human pulmonary tuberculosis alveolar pneumonia

Pulmonary tuberculosis (TB), caused by lung infection with Mycobacterium tuberculosis ( Mtb ), often manifests both alveolar pneumonia and aggregation of immune cells containing Mtb , termed granulomas, within the same lung. Here, we integrate spatial transcriptomics, single-cell RNA sequencing, high-resoluti...

R. Teles, Chaouki Benabdessalem, Jonathan Perrie et al. · 0 citations
Open access Sep 2026

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis.

RATIONALE Tuberculosis vaccines aim to elicit protective immunity, with IFNγ-producing CD4⁺ T cells considered central mediators of host defense. In murine models, IFNγ activates macrophages to induce inducible nitric oxide synthase (iNOS), resulting in nitric oxide-dependent control of Mycobacterium tuberculosis (Mtb)...

Fabian Stei, Erin F McCaffrey, Björn Zessin et al. · 0 citations
Open access Jul 2026

Machine learning-assisted directed evolution of plant Rubisco

The utility of ML-assisted evolution for engineering Rubisco with improved carboxylation efficiency and potential for enhancing crop productivity is demonstrated.

Julie L. McDonald, Jiachen Lin, Yunlong Zhao et al. · 0 citations

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