Palmitoylation is a widely employed strategy for anchoring peptides to lipid membranes, but it can also lead to uncontrolled self-assembly. The lipid moieties can promote clustering into heterodispersed aggregates that distribute unevenly, thereby reducing accessibility and inducing undesired uptake mechanisms that lim...
Juan Toledo-Marcos, Bruno Di Geronimo, Sanja Curcic et al.· Materials Advances· 0 citations
The difructose dianhydride I synthase/hydrolase α FFase 1 catalyzes the reversible transformation of inulobiose into difructose dianhydride I, a component of caramel. The proposed reaction mechanism of such a transformation consists of a glycosylation step followed by a cyclization to yield the dianhydride from the dis...
Santiago Alonso-Gil, Bruno Di Geronimo, T. Kashima et al.· Chemistry· 0 citations
A comprehensive introduction and overview of several current artificial intelligence (AI)‐driven methods available for enzyme design, with a focus on reaction‐to‐sequence design, structure prediction, substrate scope prediction, engineering of stable variants, design of enzymes with non‐canonical amino acids, and de no...
Rosa Teijeiro-Juiz, Nina Egeler, Grzegorz Jamróg et al.· Protein Science· 2 citations
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