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Brittany N. Vandenberg

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Open access Sep 2026

Widespread atypical UV-induced mutations form in single-stranded DNA

Persistence of common ultraviolet (UV)–induced lesions, like cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts (6-4-PPs), typically results in C>T substitutions at dipyrimidines: a mutation pattern that composes the single-base substitution (SBS) signature 7 in cancer. Oncogenic melanom...

Cameron Cordero, Brittany N. Vandenberg, Isabelle Mittelstadt et al. · 0 citations

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