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Author

Brian Wigdahl

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Open access Aug 2026

In vivo genome editing of central nervous system SIV reservoirs in ART-suppressed rhesus macaques

It is demonstrated that intact and potentially replication-competent virus persists in the primate brain under ART and that systemic AAV9-CRISPR can reach and edit proviral DNA in this sanctuary, supporting genome editing as a strategy toward durable remission of CNS reservoirs.

Hong Liu, Shu-Ren Liao, Chen Chen et al. · 1 citation
Open access

Characterization of a CRISPR/Cas9-based molecular recorder for HIV-1

HIV-SCRIBE is developed, a CRISPR-based molecular recorder in which a self-targeting guide RNA locus is placed under a Tat-responsive minimal HIV-1 5'LTR promoter, coupling Cas9-mediated cleavage and error-prone repair to Tat-driven transcriptional activation to generate a durable molecular record of HIV-1 reactivation...

Nahia Urturi Ortiz, M. Nonnemacher, Brian Wigdahl · 0 citations
Review Open access Jun 2026

CRISPR/Cas9-Based Genome Editing: Understanding Differences in DNA Repair Pathways, Profiles, and Outcomes

The factors that influence the generation of CRISPR/Cas9-generated repair edits, the overall profiles, and outcome prediction(s), as well as the analytical tools that have been developed to date are discussed.

Samuel N. Effah, Shirley C. Barrera, Nahia Urturi Ortiz et al. · 0 citations

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