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Author

Brian R. Herb

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Open access Aug 2026

Sensitive detection of rare HIV-infected cells in the human brain by single-nucleus RNA sequencing

A scalable multi-reference framework for detecting HIV RNA–positive cells in human CNS single-nucleus RNA-seq data is presented and provides large-scale quantitative evidence that microglia represent the dominant and most persistent HIV-infected population in the human brain.

Yuan-Yuan Cai, Nicholas C. Jacobs, Dana Gabuzda et al. · 0 citations
Open access Jul 2026

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan

A consolidated cellular-resolution transcriptomic atlas of human brain development from the onset of neurogenesis to adulthood is presented, covering ∼2.2 million cells from 156 donors across nine studies, and dynamic gene programs predictive of cell-type maturation are identified.

Sridevi Venkatesan, Patricia R. Nano, Jonathan M. Werner et al. · 0 citations

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