Open access
Aug 2026
Modified Plasmids and Inverted Terminal Repeats Enhance Adeno-Associated Virus Production and Performance
A 140% increase in pHelper plasmid production is reported, while the most successful ITR variant increased pTransgene plasmid yields by 57% and transgene expression by 28%, without reducing rAAV yields or transduction efficiency.
Nicholas Donohue, Alexandra Bogdanovic, James Conheady et al.
· International Journal of Mol... · 0 citations