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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Breanne R. Hewitt

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Open access Sep 2026

Cell-matrix interactions drive functional compartmentalization of mitochondria during 3D migration.

Cells migrating through three-dimensional (3D) tissues adapt their mechanical properties in response to extracellular matrix architecture through migratory plasticity. In primary human dermal fibroblasts, matrix elasticity drives distinct low- and high-pressure migration modes in which forces either push or pull the nu...

Breanne R. Hewitt, Jacob J. Duggan, Ryan J. Petrie · 0 citations
Review Open access

Spatial organization of mitochondria in 3D cell migration

Cell migration is a fundamental biological process required for embryonic development, tissue repair, immune surveillance, and cancer metastasis. To successfully navigate the diverse mechanical environments encountered in vivo, cells exhibit migratory plasticity, the ability to dynamically alter their migration strateg...

Breanne R. Hewitt, R. Petrie · 0 citations

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