Review
Open access
Aug 2026
Optimization of Focused Ultrasound-Mediated Blood–Brain Barrier Opening for CNS Therapeutic Delivery: Mechanistic Insights, Technical Parameters, and Clinical Translation
Background/Objectives: The blood–brain barrier (BBB) remains a major obstacle to effective gene therapy for neurological disorders by limiting delivery of viral vectors, nanoparticles, and biologics to the central nervous system. Multiple strategies have been developed to transiently disrupt or bypass the BBB, includin...
M. Rashad, Agastya Mittal, Srivardhan Chirasani et al.
· Journal of Molecular Patholo... · 0 citations