Author

Bradley F. Boeve

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Open access Oct 2026

Combining Raw Score and Normative Score Cut-Offs for Remote Digital Cognitive Screening: Impact on Sensitivity and Specificity in Cognitively Unimpaired Participants and Participants With Mild Cognitive Impairment and Dementia

Objective: The Mayo Test Drive (MTD) screening battery is a digital, self-administered, web-based cognitive assessment (Stricker et al., 2025 TCN). We aimed to compare diagnostic accuracy of raw versus normative score approaches to distinguishing cognitively unimpaired (CU) from mild cognitive impairment/mild dementi...

Morgan A. Hughes, Alyssa N. Kaser, Elizabeth A. Boots et al. · Archives of Clinical Neurops... · 0 citations

Open access Sep 2026

Smartphone Passive Digital Phenotyping in Frontotemporal Lobar Degeneration

Introduction: Frontotemporal lobar degeneration (FTLD) is a devastating disease that commonly results in early onset dementia, yet its rarity and heterogeneity limit large-scale research and clinical trials. Remote monitoring via low-burden digital health tools may overcome these barriers. We evaluated clinical utility...

E. Paolillo, Sreya Dhanam, J. Taylor et al. · medRxiv · 0 citations

Open access Aug 2026

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer’s disease

TAR DNA-binding protein of 43 kDa (TDP-43) is often found in the brains of patients with Alzheimer’s disease (AD), where it co-occurs with amyloid β plaques and tau neurofibrillary tangles, and associates with accelerated cognitive decline and brain atrophy. TDP-43’s function of repressing the inclusion of cryptic exon...

Madison M. Reeves, Sara Aviles Carpintero, M. Zanovello et al. · Alzheimer's Research & Thera... · 0 citations

Open access Sep 2026

Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer’s disease PET imaging biomarkers

INTRODUCTIONCognitive characterization is increasingly important for Alzheimers disease treatment decisions, highlighting the need for scalable cognitive assessment. We evaluated the diagnostic accuracy of a remote self-administered cognitive screening battery, Mayo Test Drive (MTD), across clinically and biologically...

N. Stricker, Elizabeth A. Boots, Rita L. Taylor et al. · medRxiv · 0 citations

#machine learning Open access Dec 2024

Enhancing brain age estimation with structural MRI and synthesized cerebral blood volume maps

Abstract Brain age gap estimation (BrainAGE) is a promising imaging-derived biomarker of neurobiological ageing and disease risk, yet current approaches rely predominantly on T1-weighted structural MRI, overlooking functional vascular changes that may precede tissue damage and cognitive decline. Deep learning-derived c...

Jordan Jomsky, Zongyu Li, K. Igwe et al. · Brain Communications · 1 citation