Open access
Aug 2026
CK2 variant function and disease modelling in Drosophila reveal allelic heterogeneity and Wnt/β-catenin-mediated phenotypes
Drosophila models of CSNK2A1 and CSNK2B expression are generated to functionally assess variant impact, and Wnt agonists partially rescue phenotypes associated with adult-specific neuronal reduction of CkII, finding that neuronal and glial CkII is critical for organismal development.
Yina Her, Danielle M Pascual, Ying Lao et al.
· bioRxiv · 0 citations