Author

Brad Broyles

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Open access Jul 2026

Hierarchy of grammar rules for the language of transcriptional activation domains

Using rational design of AD sequences and high-throughput in vivo experimentation combined with bioinformatic analysis and machine learning, grammar rules for AD sequences are refined, the relative importance of each rule is calculated to define a rule hierarchy, and each rule is linked to the biochemical features essential for biological function.

David G. Cooper, T. Y. Erkina, Brad Broyles et al. · iScience · 0 citations