Author

Boyd van Reijmersdal

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Open access Sep 2026

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

Summary Axonal and synaptic degeneration are key hallmarks of neurodegenerative diseases, but the molecular mechanisms remain incompletely understood. Here, we performed an unbiased forward genetic mosaic screen in Drosophila to identify genes required for maintenance of adult motor axons and neuromuscular junctions (N...

Marije Been, Erwan Lambert, Ana Serna et al. · iScience · 0 citations

Open access Sep 2026

The evolutionarily conserved EHMT1/G9a histone methyltransferase family regulates sleep maintenance through ROS homeostasis in insulin-producing cells

It is shown that G9a is required in insulin-producing cells (IPCs) and the fat body, in the latter during development, to ensure adult sleep integrity, and that a Drosophila sleep-restriction paradigm based on human sleep-restriction therapy can override the developmental defects and restore sleep continuity in adultho...

Mireia Coll-Tané, Lara V. van Renssen, Nicholas Raun et al. · bioRxiv · 0 citations